Pioneering Protein Splicing:

A Novel Gene Therapy Modality

SpliceBio is a genetic medicines company harnessing its proprietary Protein Splicing platform to develop the next generation of gene therapies. Our platform is based on technology developed in the Muir Lab at Princeton University after more than 20 years of pioneering intein and protein engineering research.

SpliceBio Enters Collaboration with Spark Therapeutics to Develop a Gene Therapy Targeting an Inherited Retinal Disease

BARCELONA, 17 October, 2023 – SpliceBio, a genetic medicines company harnessing Protein Splicing to develop the next generation of gene therapies, is pleased to announce the signing of an exclusive collaboration and licensing agreement with Spark Therapeutics to utilize SpliceBio’s proprietary Protein Splicing platform to develop a gene therapy for an undisclosed inherited retinal disease.



Miquel Vila-Perelló, Ph.D

Miquel co-founded SpliceBio and serves as CEO. Miquel has broad experience in biotechnology, chemical biology and protein chemistry as well as in the managing of research teams and projects. After obtaining his PhD at the University of Barcelona he carried out postdoctoral studies at The Rockefeller University. He later became a Research Scholar at Princeton University, where he managed the Protein Center at the Department of Chemistry. Over the last ten years he has contributed to the discovery and development of novel protein ligation technologies. He has authored more than 23 publications, including patent applications, and has a proven track record for the leadership of scientific teams and non-dilutive fund raising.

Silvia Frutos, Ph.D

Silvia co-founded SpliceBio and serves as CTO. Silvia has broad experience in chemical biology, protein chemistry as well as peptide synthesis. She carried out her PhD at the Barcelona Science Park. After that she moved to New York to carry out her postdoctoral studies at The Rockefeller University. Over the last ten years she has contributed to understand the mechanism of the inteins, which are essential in our protein ligation technology. Also Silvia brings deep scientific expertise and an intimate knowledge of European bioclusters.

Gerard Caelles

Gerard joined SpliceBio in 2016 as the responsible for Business Development operations. Prior to joining SpliceBio, Gerard served as the Business Development Manager at Bionure, where he was focused on business development and partnering around the company’s novel candidate in the orphan neuro-ophthalmology space, as well as on fundraising efforts. Gerard holds a BSc in Biotechnology from Universitat Autònoma de Barcelona and has been studying Mandarin Chinese for four years.

David Favre, D.V.M., Ph.D

David joined in 2023 and serves as Chief Development Officer. He brings more than 25 years of of experience in gene therapy, immunology and drug development throughout academia and the biopharma industry. He joins SpliceBio from Innoskel, where he served as Chief Scientific Officer. Prior to that, Dr. Favre was Vice President of Translational Medicine at Asklepios Biopharmaceutical (AskBio), where he led the platforms and program resources to marshal preclinical, INDs and early clinical programs, particularly focusing on the immunogenicity and adjunctive immunotherapy of AAV gene therapy and metabolic diseases. Previously Dr. Favre was the Director of HIV Biology at GlaxoSmithKline (GSK), where he spearheaded their portfolio of immunotherapy drugs. Dr. Favre has also served as Adjunct Associate Professor at the University North Carolina, Chapel Hill. r. Favre earned a D.V.M. from the Veterinary School of Nantes, France, and a Ph.D. in Microbiology from the University of Paris, which focused on the immunology of AAV gene therapy and preclinical assessment in non-human primates. He completed his post-doctoral studies in immunology at the Gladstone Institutes and at UCSF in San Francisco, US.





Board Member

Jordi Xiol

Board Member

Ed Mathers

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